3D yeast colony genomics: A model for cancer progression and development of drug resistance in biofilms
Published
Updated 23-12-2014
- region changed
| Region | National coverage |
|---|---|
| Title of the Programme | Czech-Norwegian Research Programme |
| Title of the Project | 3D yeast colony genomics: A model for cancer progression and development of drug resistance in biofilms |
| Number of the Project | 7F14083 |
| Project Promoter |
Charles University in Prague
|
| Name of Norwegian Partner(s) |
Oslo University Hospital |
| Name of Local Partner(s) |
Institute of Microbiology of the AS CR |
| Objective of the Project |
Recent findings of both Czech teams behind this project showed that yeast colonies can serve as a unique model system, where colonies behave as simple multicellular organisms formed by differentiated cells with specific properties. Intriguingly, one of the major colonial cell subpopulations gains metabolic properties similar to tumor cells. Natural yeast strains form another type of colonies that resembles fungal biofilms with specific properties which contribute to the high environmental resistance of the entire colony population. With the application of next-generation sequencing methodology provided by the Norwegian team to this model, project YEASTSEQ will contribute to uncovering of molecular mechanisms regulating colony differentiation and the knowledge gleaned will find applications in medicine. |
| Approved grant |
958 038 EUR |
| Project Duration | Start date: 15th October 2014 , End date: 30th April 2017 |