NuArch: Nuclear Architecture in the regulation of autophagy, DNA repair and gene expression
Published
Updated 23-12-2014
- region changed
| Region | National coverage |
|---|---|
| Title of the Programme | Czech-Norwegian Research Programme |
| Title of the Project | NuArch: Nuclear Architecture in the regulation of autophagy, DNA repair and gene expression |
| Number of the Project | 7F14369 |
| Project Promoter |
Institute of Biophysics Academy of Sciences of the Czech Republic |
| Name of Norwegian Partner(s) |
University of Oslo |
| Objective of the Project |
Hypothesis of NuArch project is based on the assumption that nuclear structural proteins, and their roles in gene expression regulation, are also implicated in autophagy and DNA damage repair. We expect to establish new roles for well-known nuclear structural proteins and link them to key nuclear processes which are critical for cellular homeostasis and regulation of cell growth. This will be studied in several cancer cell types, characterized by uncontrolled cell proliferation. Project is also dealing with functional properties of selected nuclear proteins, known to be implicated in a variety of rare diseases, collectively referred to as "nuclear envelopathies". |
| Approved grant |
1 088 717 EUR |
| Project Duration | Start date: 15th July 2014, End date: 30th April 2017 |