Development of standardized culture, transplantation and banking of RPE cells for treatment of age-related macular degeneration (AMD)
Published
| Region | Central Bohemian Region |
|---|---|
| Title of the Programme | Research |
| Title of the Project | Development of standardized culture, transplantation and banking of RPE cells for treatment of age-related macular degeneration (AMD) |
| Project Website | https://www.iapg.cas.cz/cs/projekty/projekty-v-reseni-a-v-udrzitelnosti/ta-cr/ |
| Number of the Project | TO01000107 |
| Project Promoter | Ústav živočišné fyziologie a genetiky AV ČR |
| Project Partner from Donor State | University of Oslo |
| Czech Partner | Fakultní nemocnice Královské Vinohrady
|
| Status | Estimated project duration: 1 / 2021 - 4 / 2024 |
| Total Eligible Costs | 1 530 049 EUR |
| Grant | 1 415 802 EUR |
Project description:
The project aims to develop a standardized, safe and efficient method for curing dry age-related macular degeneration (AMD) - the most frequent cause of visual impairment that currently lacks treatment.
The work will bring promising retina pigment epithelial (RPE) cell research to a clinical trial using patient-derived stem cell therapy.
The Specific aims are focused at:
1) isolation, cultivation and optimization of human RPE cells, primary hRPEs and induced pluripotent stem cell (iPSC)-derived RPEs;
2) preparation of nanofibrous scaffold;
3) transplantation of hRPE-covered scaffolds in the subretinal space;
4) non-invasive (OCT, mfERG) and end-stage cell and tissue characterization (IHC, tEM);
5) establishment of good manufacturing practice (GMP) protocols and clinical-grade cell banking.